Finally, having overcome normal controls on cell birth and cell death, an aspiring cancer cell faces two new challenges: it must overcome replicative senescence and become immortal and it must obtain adequate supplies of nutrients and oxygen to maintain this high rate of proliferation. We use cookies on our website to ensure you get the best experience. Please note that many of the page functionalities won't work as expected without javascript enabled. This series of review articles aims to highlight significant findings and advances in our understanding of the role of the TME in cancer biology. Topics of interest include: Following special issues within this section are currently open for submissions: Following topical collection within this section is currently open for submissions: Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. This section covers all aspects of molecular and cellular biology related to the development, progression and therapy of cancer.

Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The evolution of the normal cell to a malignant one involves processes by which genes involved in normal homeostatic mechanisms that control proliferation and cell death suffer mutational damage which results in the activation of genes stimulating proliferation or protection against cell death, the oncogenes, and the inactivation of genes which would normally inhibit proliferation, the tumor suppressor genes. Proteomics pinpoints alterations in grade I meningiomas of male versus female patients. A better understanding of the pivotal molecular events underlying these three aspects of cancer biology will aid the identification of novel targets and the development of new therapeutic approaches for the treatment of this devastating disease. 1997 Sep-Oct;21(5):233-300. doi: 10.1016/s0147-0272(97)80003-7. California Privacy Statement, 2019), nutrients (Lyssiotis and Kimmelma…  |   |  Clipboard, Search History, and several other advanced features are temporarily unavailable. 2000 Sep 25;162(39):5199-204. This detailed understanding of the process of carcinogenesis at the molecular level has only been possible because of the advent of modern molecular biology. DNA damage can also result from interactions with exogenous agents such as ionizing radiation, UV radiation and chemical carcinogens.  |  2020 Jul 28;9(8):455. doi: 10.3390/antibiotics9080455. 2020 Jun 15;4:19. doi: 10.1038/s41698-020-0122-1. Find support for a specific problem on the support section of our website. Thematic Series Published in 2020: Non-coding RNAs and RNA modifiers in cancer progression and cancer cells resistance to therapies, The role of ubiquitination and deubiquitination in cancer metabolism, Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA, Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab, Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook, Thymoquinone attenuates tumor growth in Apc, Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition, Down regulation of Thrombospondin2 predicts poor prognosis in patients with gastric cancer, The complexity of NF-κB signaling in inflammation and cancer, Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma, Featured Article: Role of the NLRP3 inflammasome in cancer, Thematic Series Published in 2019: Microvesicles and Tumor Microenvironment in Cancer Development and Resistance to Therapies, Sign up for article alerts and news from this journal, Source Normalized Impact per Paper (SNIP).

Get the latest research from NIH: https://www.nih.gov/coronavirus. Help us to further improve by taking part in this short 5 minute survey, Click here to see the Section Editorial Board of "Molecular Cancer Biology", The Isoforms of the p53 Gene Family and Their Role in Cancer and Aging：Selection Papers from International p53/p63/p73 Isoforms Workshop, Molecular Genetics of Breast and Ovary Cancer, Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles, The Intersection of Cell Death and Metabolism in Cancer, Genomic Instability and Hepatocellular Carcinoma, Blood Coagulation Factors and platelet-derived Mediators in Tumor Cell Biology, Metabolic Pathways and Redox Homeostasis in Cancer, Mechanisms of Resistance in Genito-Urinary Cancers: Innovative Insights in Signaling and Therapeutic Targetings, Molecular Biology of Ovarian Cancer: From Mechanisms of Intraperitoneal Metastasis to Therapeutic Opportunities, Targeting Blood Vessel Components to Treat Cancer, Prostate Cancer—from Molecular Mechanisms to Clinical Care. Santos JD, Vitorino I, Reyes F, Vicente F, Lage OM. Authors: Tianshui Sun, Zhuonan Liu and Qing Yang, Authors: Sailan Zou, Qiyu Tong, Bowen Liu, Wei Huang, Yan Tian and Xianghui Fu, Authors: Min Kang, Bo Tang, Jixi Li, Ziyan Zhou, Kang Liu, Rensheng Wang, Ziyan Jiang, Fangfang Bi, David Patrick, Dongin Kim, Anirban K. Mitra and Yang Yang-Hartwich, Authors: Jie Li, Maoguang Ma, Xuesong Yang, Maolei Zhang, Jingyan Luo, Huangkai Zhou, Nunu Huang, Feizhe Xiao, Bingquan Lai, Weiming Lv and Nu Zhang, Authors: Lena Horvath, Bernard Thienpont, Liyun Zhao, Dominik Wolf and Andreas Pircher, Authors: Michaela Lang, Melanie Borgmann, Georg Oberhuber, Rayko Evstatiev, Kristine Jimenez, Kyle W Dammann, Manuela Jambrich, Vineeta Khare, Christoph Campregher, Robin Ristl and Christoph Gasche, Authors: María M Caffarel, Clara Andradas, Emilia Mira, Eduardo Pérez-Gómez, Camilla Cerutti, Gema Moreno-Bueno, Juana M Flores, Isabel García-Real, José Palacios, Santos Mañes, Manuel Guzmán and Cristina Sánchez, Authors: Ruochuan Sun, Jifeng Wu, Yuanyuan Chen, Mingdian Lu, Shangxin Zhang, Daru Lu and Yongxiang Li, Authors: Bastian Hoesel and Johannes A Schmid, Authors: Reason Wilken, Mysore S Veena, Marilene B Wang and Eri S Srivatsan, Special Issue to be published in early 2021 on ‘mRNA-based therapies and vaccines for human cancers’, All papers selected by Editor in Chief, Professor Christophe Nicot, Submit your paper for consideration  today - deadline for submission is November 30th, 2020. Cookies policy. 2020 Jul 2;9(7):150. doi: 10.3390/biology9070150. This review does not attempt to be comprehensive but identifies key genes directly involved in carcinogenesis and demonstrates how mutations in these genes allow cells to circumvent cellular controls. Here, the fittest cell is one that survives to form a new population of genetically distinct cells, the tumor. In this review, Sahebkar et al. 2020 Jun 25;12(6):592. doi: 10.3390/pharmaceutics12060592.